USPTO Patents Application 09993647

Requested Patent:

JP55162772A

Title:

PREPARATION OF SUBSTITUTED ACETIC ACID DERIVATIVE ;

Abstracted Patent:

JP551 62772 ;

Publication Date:

1980-12-18 ;

Inventor(s):

HAMADA YOSHINORI; others: 01 ;

Applicant(s):

SHIONOGI _CO LTD ;

Application Number:

JP1 9800069434 19800523 ;

Priority Number(s): ;
IPC Classification:

C07D213/64; C07D213/65; C07D213/68; C07D213/70; C07D213/82; C07D213/85;
C07D215/22; C07D217/14; C07D217/24; C07D235/26; C07D239/32 ;

Equivalents: ;

ABSTRACT:

NEW MATERIALA substituted acetic acid derivative of formula I (formula II is pyridine,
pyrimidine, imidazole or tetrazole; R is hydrocarbon group; A is O or S; formula II and the
benzene ring may have a 1-3C substituent, condensed benzene ring or alicyclic ring which will
not affect the reaction; -COR may be on the condensed benzene ring).

EXAMPLE:2-(2-Phenoxy-5-pyridyl)-propionic acid. USE:A medicine or drug for an animal having
improved anti-inflammatory action (including an antirheumatic action) and an analgesic action.
PROCESS:A compound of formula III is reacted with an alkoxymethylene-trihydrocarbon
group-substituted phosphorane to give a compound of formula IV, which is hydrolyzed and
oxidized to form the compound of formula I. The compound of formula III can be obtained by
reacting a halogenopyridine with a phenol or thiophenol in the presence of a basic substance if
necessary.

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